In recent years, significant advancements have been made in drug delivery systems using microneedles. Researchers have developed a rocket microneedle drug delivery system that uses a self-propulsion mechanism for deep penetration into the skin and tumor microenvironment. This article discusses the use of rocket microneedles made of mesoporous silica nanoparticles and other materials for the treatment of melanoma, a type of skin cancer.
Bladder cancer, particularly non-muscle invasive bladder cancer (NMIBC), is the most common malignant tumor of the urinary system. Although platinum-based chemotherapy has shown significant clinical efficacy as a first-line treatment, its therapeutic effect is still limited for patients with lymphovascular invasion (LVI). The formation of LVI is closely related to platelets, which not only hinder drug delivery but also protect tumor cells from chemotherapy-induced cell death and immune attack.
A recent study utilizing mesoporous silica nanoparticles (MSN) loaded with trehalose dimycolate (TDM) has shown promise in enhancing the anti-tumor effects of combining the nanoparticles with the WRN nuclease. The research was recently published in Advanced Science on August 29, 2024.
In the preparation of oxide powders, specific surface area is a very important indicator, which directly affects the performance and application of the powder. However, the specific surface area is influenced by many factors, the most important of which is the preparation method. Different preparation methods can lead to differences in the size, shape, and porosity of powder particles, which in turn affect their specific surface area. Therefore, when choosing a preparation method, it is necessary to select the appropriate process based on specific application requirements.
Iron oxide nanoparticles are extensively studied for their use in medical applications due to their unique magnetic properties. However, one of the major concerns with the use of inorganic nanoparticles is their potential biotoxicity. Inorganic nanoparticles have a slow clearance kinetics that can pose a potential threat to their in vivo application. The clearance of nanoparticles from the body largely depends on the surface physicochemical properties rather than their size and shape.
Osteoarthritis (OA) is a prevalent disease characterized by subchondral bone fracture, and there is no accurate and specific treatment yet available. Recently, the research team has synthesized a new multifunctional scaffold that can potentially solve this problem. Using photo-polymerized modified hyaluronic acid (GMHA) as a substrate and hollow porous magnetic microspheres (HAp-Fe3O4) as the base, they designed a scaffold with optimum properties for subchondral bone repair.
