The accurate diagnosis and treatment of acute ischemic stroke (AIS) require high sensitivity and resolution imaging technologies. Unfortunately, such technologies are still lacking in the field. However, on July 4th, 2024, Small reported the development of a Contrast-Enhanced Susceptibility-Weighted Imaging (CE-SWI) technique that is capable of meeting high-precision imaging needs. The technique employs Fe3O4 nanoparticles modified by Dextran (Fe3O4@Dextran NPs), which allows for high sensitivity and resolution imaging of AIS at 9.4T.
Fe3O4@Dextran NPs’ advantages include small size (fluid dynamic diameter of 25.8 nm), excellent solubility, high transverse relaxation rate (r2 reaches 51.3 mM-1s-1 at 9.4T), and good biocompatibility. Researchers synthesized the Fe3O4@Dextran nanoparticles using a simple co-precipitation method at room temperature.
The Fe3O4@Dextran NPs-enhanced SWI can effectively highlight the cerebral vessels and significantly enhance contrast under 9.4T MRI, achieving a resolution as high as 0.1mm. As a result, the Fe3O4@Dextran NPs-enhanced SWI can clearly identify the spatial distribution of collateral circulation in the middle cerebral artery occlusion (MCAO) rat model.
Furthermore, through matches and analyses with other multimodal MRI sequences, the Fe3O4@Dextran NPs-enhanced SWI helps accurately depict the ischemic core, collaterals, and penumbra in AIS.
These findings bring new hope for the early diagnosis and effective treatment of AIS with a higher resolution and sensitivity.
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