A recent study utilizing mesoporous silica nanoparticles (MSN) loaded with trehalose dimycolate (TDM) has shown promise in enhancing the anti-tumor effects of combining the nanoparticles with the WRN nuclease. The research was recently published in Advanced Science on August 29, 2024.
The research took a unique approach to develop a new anti-tumor strategy, utilizing the dual-inducing effects of MSN and TDM to construct a mouse subcutaneous tumor model. The team observed the nanoparticles' anti-tumor effectiveness in inducing fibrosis, potentially inhibiting malignant progression by transforming tumor cells into fibroblasts.
Using both in vitro and in vivo research, the team discovered that TDM/MSN (TM) nanoparticles could effectively enter solid tumors and induce fibrosis, leading to collagen internalization and a reduction in the proliferation and invasion ability of tumor cells. However, the team also found that chromosomal extracellular DNA (ecDNA) mediated resistance to fibrosis induction.
To address this resistance, the research team utilized WRN nuclease to develop a new nanoparticle combination, TMW. This combination effectively cleared ecDNA and promoted tumor cell transformation to fibroblast-like cells, demonstrating its ability to inhibit cancer progression in PDX models.
Overall, the research findings discovered the potential of TDM/MSN-WRN (TMW) nanoparticles in inducing fibroblast transformation and collagen deposition, thereby inhibiting malignant progression. Further studies could develop this promising anti-tumor strategy and improve patients' cancer survival and quality of life.
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